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KMID : 0869619940110010026
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Journal of Korean Society of Hospital Pharmacists
1994 Volume.11 No. 1 p.26 ~ p.29
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Content uniformity and Dissolution rate of Diazepam tablets
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Abstract
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Drug effect depend on bioavailability of preparation and also bioavailability is largely depend on dissolution rate and content uniformity. This study was attempted to evaluate bioavailability of preparations for drug choice among preparations by dissolution test and content uniformity test of commercial diazepam tablets. Diazepam is benzodiazepines and has sedative action. The dissolution test was conducted in artificial gastric juice and artificial intestinal juice using Basket method with four diazepam preparations (A, B, C, D) which were pharmaceutically equivalent.
The results were as following:
1) The dissolution rate in artificial gastric juice was higher in the order of four different brands D>A>B>C.
2) The dissolution rate in artificial intestinal juice was higher in the order of four different brands B>A>C>D.
3) Content uniformity of four different brands was better in such order as D>B>C>A. The relationship between each results was not established.
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